Loans

Mufti Saab, Aslm. Just a simple question, i tried to look for it on other Q&A but could not find it.
Is it permissible to take an interest bearing loan? In either of the following cases,
1.for buying a car,
2.a house
3. wedding or
4. going on holidays?
5. If the above is yes, is it permissible to take an interest bearing loan to go umrah?
Jazak Allah Khair